Causes of Renal FailureRenal failure takes place when one or both of your kidneys are unable to cleanse your blood or separate it from all the waste substances and products mixed in with it. On losing this ability, a high level of toxic wastes start accumulating in your blood and can cause a severe imbalance of electrolytes and hormones in your body.

Take a look at some of the major causes of kidney failure.

Impaired or Slow Flow of Blood to the Kidneys

If blood does not flow smoothly to your kidneys, then the chances of you suffering from kidney failure become higher. You can experience an impaired flow of blood if you are suffering from a cardiac arrest, heart disease or disorder, loss of blood or body fluids, infections, liver failure, harsh dehydrations, and burns.

Moreover, various infections, allergic reactions and burns can also slow down the blood flow to your kidneys, resulting in renal failure. If you use aspirin, naproxen (Aleve or others) and ibuprofen (Motrin IB, Advil and others), then your odds of acquiring kidney failure will become higher.

Damage Inflicted on the Kidneys

If your kidneys become damaged or harmed, you are put at the risk of suffering from kidney failure. This can result from any blood clots that are present in your arteries and veins surrounding your kidneys, or if cholesterol starts accumulating in the veins that transfer blood to your kidneys.

Moreover, various body infections, accumulation of toxins like cocaine, alcohol and heavy metals, onset of thrombotic thrombocytopenic purpura (TTP) and inflammation of your blood vessels known as vasculitis can also result in renal failure. If you have cancer of the plasma cells, known as multiple myeloma, or if are suffering from scleroderma, which affects your connective tissues and skin, then you could suffer from kidney failure. Apart from that, the inflammation of the glomeruli in your kidneys, which is known as glomerulonephritis, Lupus and Hemolytic uremic syndrome, can also cause renal failure.

Hemolytic uremic syndrome is a condition that takes place when your red blood cells are destroyed prematurely. Several medications, including antibiotis, chemotherapy medicines, and dyes employed during zoledronic acid test, and the imaging test can also put you at the risk of getting renal failure.

Blockage of Urine in the Kidneys

If you are unable to urinate properly and are suffering from diseases that result in the blockage of urine, then you may suffer from acute renal failure. The conditions that can cause blockage of urine include cervical cancer, bladder cancer, blood clots in your urinary tract, formation of stones in the kidneys, colon cancer, prostate cancer, an enlarged prostate gland, and damaged nerves that are used for controlling your bladder.

 

Chronic Kidney Disease

If you are suffering from chronic kidney disease, then your chances of getting kidney failure increase simultaneously. Diabetes mellitus is one of the biggest causes of chronic kidney disease. Moreover, if you are suffering from hypertension, your chances of getting chronic kidney disease are higher than the person who isn’t experiencing hypertension.

The onset of polycystic kidney disease can also result in chronic kidney disease that eventually causes renal failure. Normally, people who have a widespread family history of polycystic kidney disease acquire this disease.

Using an excessive dose of ibuprofen, acetaminophen (paracetamol) or aspirin can also result in chronic kidney failure. Diseases like hantavirus can also make you the victim of this disease.

Genetic Disorder

A genetic predisposition can also result in renal failure. The APOL1 gene is known for causing non-diabetic kidney failure in people of an African descent.

In addition, as stated above, polycystic kidney disease (PKD) can also cause renal failure. This disease is also associated with genetic predisposition and results in the growth of numerous cysts in the kidneys. These cysts begin damaging the kidneys, resulting in permanent renal failure. These are different from the normal kidney cysts that grow in your kidneys as your grow and age.

These cysts are normally benign and do not pose any threat to your kidneys. On the other hand, the cysts formed during PKD are malignant and can inflict serious harm to your kidneys.

Getting Checked for these Causes

To ensure that you do not acquire any of these diseases discussed above and are able to keep kidney failure at bay, you need to get yourself thoroughly examined if you feel you are suffering from these problems. You will be advised to undergo certain tests by your doctor.

These tests include urine tests, urine output measurement tests, blood tests to check any rise in the levels of creatinine and urea, different imaging tests such as computerized tomography (CT) and ultrasounds, and a kidney biopsy. During biopsy, a needle is inserted through your skin and into your kidney, and a small piece of the kidney tissue is removed. This sample is then tested for any anomaly occurring in your kidneys.

Once all the tests are carried out, your doctor will advise you a suitable treatment, according to your condition.  

References

http://www.mayoclinic.org/diseases-conditions/kidney-failure/basics/causes/con-20024029

http://en.wikipedia.org/wiki/Renal_failure

http://www.mayoclinic.org/diseases-conditions/kidney-failure/basics/tests-diagnosis/con-20024029

http://www.kidneyfund.org/kidney-health/kidney-failure/

http://www.kidneyfund.org/kidney-health/kidney-problems/polycystic-kidney-disease.html